Which question indicates that you want the client to be comfortable?

The question "Should I adjust your pillow?" directly addresses the comfort of the client, indicating a willingness to make their immediate physical environment more pleasant. This type of inquiry demonstrates attentiveness to the client's needs and conveys a sense of care and consideration for their comfort level.

In contrast, the other questions focus more on different aspects of the client's care. Asking about readiness for medication pertains to the client’s preparedness for a medical routine rather than their comfort. Inquiring about appetite and exercise relates to their overall health and daily activities, which, while important, do not specifically address their comfort at that moment. Only the question about adjusting the pillow explicitly seeks to enhance the client's physical comfort, making it the most appropriate choice.