What does drug tolerance refer to?

Drug tolerance refers to the phenomenon where the body becomes accustomed to a particular medication over time, resulting in a decreased response to the drug. This means that as a person continues to take the same dose of a medication, the intended effects may diminish. Consequently, the individual might require a higher dose of the medication to achieve the same effect that was initially experienced at a lower dose. This process often occurs due to physiological changes in the body, such as alterations in drug metabolism or receptor desensitization.

Understanding drug tolerance is crucial in healthcare because it can impact the management of a patient's treatment plan and may increase the risks of side effects or dependence. Recognizing that the same dose of a drug is less effective over time helps healthcare providers make informed decisions about dosage adjustments or alternative therapies.